Tuazon predominantly works with architectural techniques and materials, creating structures and spaces which use building supplies such as steel, glass, and wood and a simple do-it-yourself approach. Tuazon’s sculptures, built by hand, are often quasi-functional objects or models of other spaces. The construction process itself can often be seen as a performative part of the work, as it references the techniques of Land Art and Minimalism in improvised collaborations with designers, engineers, and builders to produce large-scale installations and public projects.

Solo exhibitions have been dedicated to his work by institutions in the U.S.A. and in Europe, such as the Kunsthalle Bergen, Bergen (2023); Kunsthalle Bielefeld, Bielefeld (2023); Kunst Museum Winterthur, Winterthur (2023); Aspen Museum of Art, Aspen (2019); Bellevue Art Museum, Seattle (2019); Hammer Museum, Los Angeles (2016); Consortium, Dijon (2015); deCordova Sculpture Park and Museum, Lincoln (2014); Museum Ludwig, Cologne (2014); Museum Boijmans Van Beuningen, Rotterdam (2013); Schinkel Pavillon, Berlin (2013); Kunsthalle Bern, Bern (2010); Centre international d’art et du paysage, Île de Vassivière (2009).

His work has been exhibited in numerous group exhibitions around the world, among them the Chicago Architecture Biennial, Chicago (2019); Skulptur Projekte, Münster (2017); Documenta 14, Athens (2017); Triennale d'art contemporain de Beaufort, Beaufort (2015); Whitney Biennial, New York (2012); Venice Biennale, Venice (2011).

He has been selected for several public commissions, in 2016 with the project Un Pont, for the Nouveaux Commanditaires of the Fondation de France, Belfort and in 2013 with People, Public Art Fund, Brooklyn Bridge Park, New York. In October 2017, FIAC gave him carte blanche to present an in situ project Une colonne d'eau, on the prestigious Place Vendôme.

Work by the artist is held in the following collections: The Museum of Modern Art, New York; Musée National d’Art Moderne, Centre Georges Pompidou, Paris; Marciano Art Foundation, Los Angeles; Zabludowicz Collection, London; Collection Museum Boijmans Van Beuningen, Rotterdam; David Roberts Art Foundation, London; FRAC Île-de-France, Paris; Musée d'Art Moderne de Paris; Kunsthaus Zürich, Zürich; Migros Museum of Contemporary Art, Zürich; Saatchi Gallery Collection, London; Giuliani Foundation, Roma; The Silvie Fleming Collection, London.