Since the early 2000s, Guyton has pursued, with a notable consistency, an investigation into the condition and impact of digital image production. Guyton purposefully misuses his printer by challenging its commands and materials that exceed its design specifications. As a result, the digital work everts its inherent conflicts questioning the conditional nature of its visualization.

In his latest series, Guyton intensifies the interplay between painting and photography by integrating cellphone snapshot of paintings drying on the floor, views of and from the studio, screen captures, and enlarged bitmaps.

Wade Guyton is a recipient of the American Academy of Arts and Letters, Award in Art (2014); the Foundation for Contemporary Performance Arts (2004); the Socrates Sculpture Park Emerging Artist Grant (2003); the Artists Space Independent Projects Grant (2002); the Delfina Studio Trust (2000).

Wade Guyton has had major solo exhibitions at the Museum Ludwig, Cologne (2019); Serpentine Gallery, London (2017); Brandhorst Museum, Munich (2017); Museo MADRE, Naples (2017); MAMCO, Geneva (2016); Le Consortium, Dijon & Académie Conti, Vosne-Romanée (2016); Kunsthalle Zürich, Zürich (2013); Whitney Museum of American Art, New York (2012-2013); Museum Ludwig, Cologne (2010); the Museum Dhondt-Dhaenens, Deurle (2009); Museum d’Arte Moderna (MAMbo), Bologna (2008); The Portikus, Frankfurt am Main (2008); Kunstverein Hamburg, Hamburg (2005), among others.

He was also featured in several international group shows and Biennales such as Fondazione Prada, Venise (2021) ; Kanal - Centre Pompidou, Brussels (2020) ; The Kitchen, New York (2020); Frac Normandie Rouen, Rouen (2020); Museum of Modern Art, New York (2019); Fondation Louis Vuitton, Paris (2019); Aïshti Foundation, Beirut (2016); Fridericianum, Kassel (2016); Fondation Beyeler, Basel (2015); Kunsthall Oslo, Oslo (2014); Punta della Dogana, Venice (2016); Venice Biennale (2013); Musée d’art moderne et contemporain (MAMCO), Geneva (2013); Museum of Modern Art, San Francisco (2013); Guggenheim Museum, Bilbao (2011); Hammer Museum, Los Angeles (2008); Whitney Biennial (2004).

His works have joined the collections of the Musée d’Art Moderne de la Ville de Paris, Paris; Art Institute of Chicago; Museum of Modern Art, New York; Whitney Museum of American Art, New York; FRAC Ile-de-France — Le Plateau, Paris; Musee D’art Moderne et Contemporain (MAMCO), Geneva; Neue Pinakothek, Münich; Kunsthaus Zürich, Zürich; Musée National d'Art Moderne, Centre Georges Pompidou, Paris; Museum of Art, Dallas; Kunstmuseum, Basel; Museum Ludwig, Cologne; Museum of Contemporary Art, Chicago; Museum of Contemporary Art, Los Angeles; Museum of Modern Art, San Francisco; Pinakothek der Moderne, Münich; Princeton University Art Museum.